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Robotic Lab Assistant


Scientific Publications

Scientific Publications – MTX (Non-Invasive Matrix Monitor)

Oximeter Behavior While Using a Tourniquet

This letter is a case report presenting the behavior of an approved for marketing oximeter device under tourniquet test, while comparing it with another approved for marketing device, the Cnoga TensorTip MTX (this letter is not a clinical trial report). Pulse oximeter is aimed for measuring pulse and arterial oxygen saturation (SpO2) in the blood. The Tensor Tip MTX can measure over 15 bio parameters, among them are pulse and oxygen saturation.

New Method for Computing Optical Hemodynamic Blood Pressure

Hypertension is a major risk indicator for coronary heart diseases, renal failure, stroke and other various illnesses, and it is the primary global risk for mortality. Blood pressure measurements are essential for managing the risks resulting from hypertension. In this paper we will present a new device, the TensorTip MTX, which computes hemodynamic blood pressure noninvasively. Methods: This paper presents a technique that uses the color imaging resulting from a set of monochrome light source that traverse the tissue under consideration and is projected onto the color image sensor. A new extended solution of the Windkessel model is being displayed and provides additional insight on various functional resistances rather than a constant resistance.

Post Marketing Study of Hemodynamic and Hematological Noninvasive Readings in a Blood Bank

This validation test was conducted in the Fujisan Blood Bank, Fortaleza, Brazil and evaluated the noninvasive TensorTip MTX (MTX, Cnoga Medical Ltd.) readings of hemoglobin, hematocrit, red blood cells, blood pressure, and heart rate compared to reference lab device readings. A total of 334 subjects were included in the Fujisan blood bank validation (65% male, 35% female). There was no statistically significant difference between the average daily hemoglobin, hematocrit, and red blood cells measurements provided by the MTX device and the laboratory hematology analyzer. In addition, there was no significant difference between the daily blood pressure and heart rate results provided by the MTX device and the digital and manual sphygmomanometers. The error calculated between the MTX and the reference device was found to be sufficiently accurate according to the relevant standards.

Measuring Balance In High Altitude

Due to Hypoxia and hypobaric conditions at high altitudes, oxygen saturation decreases. Ataxia might occur and the ability to maintain balance in challenges.This study aimed to determine whether a new balance assessment test, the Zur Balance Scale (ZBS) is sensitive enough to detect changes in the balance at high altitudes.

Scientific Publications – CoG (Hybrid Non-Invasive Combo Glucometer)

Device and Method for Noninvasive Glucose Assessment

This article presents the TensorTip Combo Glucometer (CoG), developed by Cnoga Medical Ltd, which enables to predict capillary tissue glucose concentration noninvasively. The device was clinically evaluated and compared to standard invasive blood glucose monitoring devices in few medical centers and by home users. Based on consensus error grid analysis, more than 98% of the measurements of each study were in zones A (more than 81%) and B (more than 11%). Post- marketing evaluations showed high correlations comparing the CoG to other invasive reference devices.

Evaluation of New Noninvasive Glucose Monitoring Device by Means of Standarized Meal Experiments

This study presents the performance of the CoG (the invasive and the noninvasive components) during a standardized meal experiment. Each of the 36 participants received a device for conducting calibration at home. Thereafter, they ingested a standardized meal. Blood glucose was assessed from capillary blood samples by means of the (non)invasive device, YSI Stat 2300 plus, Contour Next at different time points. For the noninvasive (NI) CoG technology, 100% of the data pairs were found in CEG zones A (96.6%) and B (3.4%); 100% were seen in zone A for the invasive component and Contour Next. MARD was calculated to be 4.2% for Contour Next, 9.2% for the invasive component, and 14.4% for the NI component. Therefore, after appropriate individual calibration of the NI technology, both the NI and the invasive CoG components reliably tracked tissue and blood glucose values, respectively. This may enable patients with diabetes to monitor their glucose levels frequently, reliably, and most of all pain-free.

New Paradigm of Personalized Glycemic Control Using Glucose Temporal Density Histograms

A paradigm change of the existing model of diabetes control is proposed, shifting from standardized treatment algorithms based on HbA1c follow-up to a new controlling approach that is based on the personal glucose density histogram. The histogram is an informative, detailed tool for the current patient glycemic behavior, and a future histogram can be targeted for a successful treatment. In addition, the glucose burden and the glucose severity index are proposed as informative markers for successful treatment. This is applicable to any glycemic data, by means of invasive and noninvasive glucometers.

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